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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnb1lGt(OST35527)Lex
gene trap OST35527, Lexicon Genetics
MGI:3530640
Summary 3 genotypes


Genotype
MGI:5428437
hm1
Allelic
Composition		 Gnb1lGt(OST35527)Lex/Gnb1lGt(OST35527)Lex
Genetic
Background		 B6;129S5-Gnb1lGt(OST35527)Lex/Orl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnb1lGt(OST35527)Lex mutation (2 available); any Gnb1l mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:82809 )
• lethality of homozygous mutant mice during early gestation




Genotype
MGI:5428438
ht2
Allelic
Composition		 Gnb1lGt(OST35527)Lex/Gnb1l+
Genetic
Background		 B6;129S5-Gnb1lGt(OST35527)Lex/Orl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnb1lGt(OST35527)Lex mutation (2 available); any Gnb1l mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal spleen B cell follicle morphology ( J:82809 )
• lymphoid depletion of splenic lymphoid follicles

homeostasis/metabolism
increased circulating bilirubin level ( J:82809 )
• total bilirubin levels were elevated in half of the heterozygous mice and were in the high range for the majority of the remaining heterozygous animals

immune system
abnormal spleen B cell follicle morphology ( J:82809 )
• lymphoid depletion of splenic lymphoid follicles
glomerulonephritis ( J:82809 )
• microscopic analysis revealed membranous glomerulonephritis

renal/urinary system
glomerulonephritis ( J:82809 )
• microscopic analysis revealed membranous glomerulonephritis




Genotype
MGI:3640307
ht3
Allelic
Composition		 Gnb1lGt(OST35527)Lex/Gnb1l+
Genetic
Background		 B6.Cg-Tyrc-Brd Gnb1lGt(OST35527)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnb1lGt(OST35527)Lex mutation (2 available); any Gnb1l mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased prepulse inhibition ( J:110101 )
• PPI is significantly impaired; mice have reduced PPI




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory