Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dlc1tm1Lec
Name:	deleted in liver cancer 1; targeted mutation 1, Laboratory of Experimental Carcinogenesis
MGI ID:	MGI:3529997
Synonyms:	DLC-1-
Gene:	Dlc1  Location: Chr8:37034905-37420297 bp, - strand  Genetic Position: Chr8, 23.05 cM, cytoband A4-B2
Alliance:	Dlc1tm1Lec page

Germline Transmission:	Earliest citation of germline transmission: J:96194
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5, encoding a serine-rich domain, was replaced with a neomycin resistance gene, causing a frame shift that resulted in a premature stop codon. The synthesized truncated protein should contain only the first 77 amino acids, which encode the SAM domain and 23 novel residues due to the reading frame shift, however, Northern blots of heterozygous animals did not demonstrate such a truncated transcript. (J:96194)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlc1 Mutation:	227 strains or lines available

Original:	J:96194 Durkin ME, et al., DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett. 2005 Feb 14;579(5):1191-6
All:	2 reference(s)