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Efnb2tm2Sor
Targeted Allele Detail
Summary
Symbol: Efnb2tm2Sor
Name: ephrin B2; targeted mutation 2, Philippe Soriano
MGI ID: MGI:3526818
Synonyms: B2GFP, Efnb2GFP, Efnb2-H2BGFP, ephrin-B2GFP
Gene: Efnb2  Location: Chr8:8667434-8711242 bp, - strand  Genetic Position: Chr8, 3.42 cM
Alliance: Efnb2tm2Sor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115952
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe H2B-GFP cDNA was inserted into exon 1 replacing a fragment of DNA including the start codon. RT-PCR analysis confirmed the absence of RNA expression in homozygous embryos. (J:115952)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 66 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Efnb2 Mutation:  28 strains or lines available
References
Original:  J:115952 Davy A, et al., Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Sep;4(10):e315
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory