Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm2Sor mutation
(1 available);
any
Efnb2 mutation
(28 available)
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mortality/aging
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• early embryonic lethality occurs in all homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm2Sor mutation
(1 available);
any
Efnb2 mutation
(28 available)
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mortality/aging
embryo
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• increase in cell death accompanies reduction in neural crest cell numbers
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• the streams of cells migrating towards the first and second branchial arches are reduced in size
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• disruption of trunk migration with scattered migration pattern and loss of normal segmented migration
• in the trunk neural crest cells invade the posterior part of somites
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• often smaller and hypoplastic
• in 12 of 21 embryos there is a severe reduction in the size of the first branchial arch
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• selective reduction in cranial neural crest cells
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• impaired differentiation
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• GFP expression indicates that cells normally confined to the caudal part of the somite are present in the rostral part
• expression analysis suggests a defect in somite patterning
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• expression analysis suggests a defect in somite patterning
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nervous system
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• selective reduction in cranial neural crest cells
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craniofacial
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• often smaller and hypoplastic
• in 12 of 21 embryos there is a severe reduction in the size of the first branchial arch
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cellular
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• increase in cell death accompanies reduction in neural crest cell numbers
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• the streams of cells migrating towards the first and second branchial arches are reduced in size
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• disruption of trunk migration with scattered migration pattern and loss of normal segmented migration
• in the trunk neural crest cells invade the posterior part of somites
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Sor mutation
(0 available);
any
Efnb1 mutation
(15 available)
Efnb2tm2Sor mutation
(1 available);
any
Efnb2 mutation
(28 available)
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craniofacial
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at E18.5, the frontal bone never overlaps at the coronal suture
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at 16.5, osteroblastic differentiation is delayed
• at E18.5, the frontal bone never overlaps at the coronal suture
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skeleton
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at E18.5, the frontal bone never overlaps at the coronal suture
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at 16.5, osteroblastic differentiation is delayed
• at E18.5, the frontal bone never overlaps at the coronal suture
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Sor mutation
(0 available);
any
Efnb1 mutation
(15 available)
Efnb2tm2Sor mutation
(1 available);
any
Efnb2 mutation
(28 available)
|
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craniofacial
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• calvaria development is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Sor mutation
(0 available);
any
Efnb1 mutation
(15 available)
Efnb2tm2Sor mutation
(1 available);
any
Efnb2 mutation
(28 available)
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digestive/alimentary system
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• about 40% smaller than in wild type controls
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vision/eye
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• at E18.5 eyelids are not fused
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respiratory system
endocrine/exocrine glands
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• about 40% smaller than in wild type controls
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skeleton
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1.1Sor mutation
(0 available);
any
Efnb1 mutation
(15 available)
Efnb2tm2Sor mutation
(1 available);
any
Efnb2 mutation
(28 available)
|
|
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digestive/alimentary system
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• about 40% smaller than in wild type controls
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vision/eye
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• at E18.5 eyelids are not fused
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respiratory system
endocrine/exocrine glands
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• about 40% smaller than in wild type controls
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skeleton
Analysis Tools
