Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plce1tm1Tkat
Name:	phospholipase C, epsilon 1; targeted mutation 1, Tohru Kataoka
MGI ID:	MGI:3525208
Synonyms:	PLCepsilon-, PLCepsilondeltaX
Gene:	Plce1  Location: Chr19:38469557-38773474 bp, + strand  Genetic Position: Chr19, 33.16 cM
Alliance:	Plce1tm1Tkat page

Germline Transmission:	Earliest citation of germline transmission: J:94952
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo was inserted to replace the 3' end of one of the four exons encoding the X domain. RT-PCR demonstrated the presence of a shortened transcript in mutant heart samples. Sequence analysis revealed a deletion of another upstream exon, presumably caused by exon skipping upon RNA splicing. The resulting allele contains an in-frame deletion of amino acids 1333 to 1408, corresponding to the amino terminal end of the catalytic X domain. (J:94952, J:97661)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plce1 Mutation:	110 strains or lines available

Original:	J:94952 Bai Y, et al., Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res. 2004 Dec 15;64(24):8808-10
All:	10 reference(s)