Erbb2tm7(Erbb2)Mul
Targeted Allele Detail
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Symbol: |
Erbb2tm7(Erbb2)Mul |
Name: |
erb-b2 receptor tyrosine kinase 2; targeted mutation 7, William J Muller |
MGI ID: |
MGI:3521860 |
Synonyms: |
Erbb2Y1227F |
Gene: |
Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
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Alliance: |
Erbb2tm7(Erbb2)Mul page
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Allele Type: |
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Targeted (Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Erbb2tm7(Erbb2)Mul expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Erbb2 (24337) |
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Expresses rat Erbb2 cDNA with a Y1227F mutation |
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Mutation details: A targeting vector was designed to replace the first coding exon with the rat Erbb2 cDNA with the Y1227F mutation, resulting in the loss of the direct binding site for Shc1. A neo was also inserted. Analysis of the RT-PCR product indicated that mutants only expressed the rat cDNA.
(J:94397)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Erbb2 Mutation: |
59 strains or lines available
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Original: |
J:94397 Chan R, et al., Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development. 2004 Nov;131(22):5551-60 |
All: |
1 reference(s) |
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