Mmp13tm1Smk
Targeted Allele Detail
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| Symbol: |
Mmp13tm1Smk |
| Name: |
matrix metallopeptidase 13; targeted mutation 1, Stephen M Krane |
| MGI ID: |
MGI:3521852 |
| Synonyms: |
Mmp-13-, Mmp13- |
| Gene: |
Mmp13 Location: Chr9:7272514-7283331 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
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| Alliance: |
Mmp13tm1Smk page
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Long bone analysis from wild type and Mmp13tm1Smk/Mmp13tm1Smk mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:94723
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A targeting vector was designed to insert a PGK-neo and a stop codon in order to splice out exon 5, which encodes the zinc-binding residues in the catalytic domain. Northern blot of mutant calvariae demonstrated a lack of transcript when an exon 5 probe was used and a barely detectable amount of transcript when using a 5' probe. Western blot showed no protein in cultures of mutant calvariae.
(J:94723)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mmp13 Mutation: |
33 strains or lines available
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| Original: |
J:94723 Inada M, et al., Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17192-7 |
| All: |
18 reference(s) |
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Analysis Tools
