Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnn4tm1Jemn
Name:	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, James E Melvin
MGI ID:	MGI:3521668
Synonyms:	IK1-, KCa3.1, KCa3.1-, Kcnn4-
Gene:	Kcnn4  Location: Chr7:24069750-24084635 bp, + strand  Genetic Position: Chr7, 10.37 cM
Alliance:	Kcnn4tm1Jemn page

Germline Transmission:	Earliest citation of germline transmission: J:94478
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was deleted upon incorporation of a PGK-neo cassette into the locus. Northern blot showed a lack of transcript in mutant CD4+ T lymphocytes. (J:94478)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kcnn4 Mutation:	18 strains or lines available

Original:	J:94478 Begenisich T, et al., Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12;279(46):47681-7
All:	27 reference(s)