Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Egfrtm1Dwt Name: epidermal growth factor receptor; targeted mutation 1, David W Threadgill MGI ID: MGI:3513096 Synonyms: Egfrfl Gene: Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4 Alliance: Egfrtm1Dwt page

Placenta abnormalities in Egfrtm1Dwt/Egfrtm1Dwt Tg(EIIa-cre)C5379Lmgd/0 mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:145161
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. Transient cre expression was used to remove the neo cassette leaving exon 3 floxed. (J:145161)

Generation of the Egfrtm1Dwt allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:	85 strains or lines available

Original:	J:145161 Lee TC, et al., Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis. 2009 Feb;47(2):85-92
All:	62 reference(s)