All Phenotypes Egfr<tm1Dwt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Egfr^tm1Dwt/Egfr^tm1Mag	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:3834094
cn2	Egfr^tm1Dwt/Egfr^tm1Dwt Sox9^tm3(cre)Crm/Sox9⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:6241557
cn3	Egfr^tm1Dwt/Egfr^tm1Dwt Tg(KRT14-cre)1Amc/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA	MGI:3834096
cn4	Egfr^tm1Dwt/Egfr^tm1Dwt Tg(KRT14-cre)1Amc/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3834097
cn5	Egfr^tm1Dwt/Egfr^tm1Dwt Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3834095

Allelic Composition	Egfr^tm1Dwt/Egfr^tm1Mag
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Dwt mutation (1 available); any Egfr mutation (88 available)
Egfr^tm1Mag mutation (1 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:145161 )

N	• mice are fertile

growth/size/body

growth/size/body region phenotype ( J:145161 )

N	• mice exhibit normal body weight

integument

integument phenotype ( J:145161 )

N	• mice exhibit normal coat color

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

impaired skin barrier function ( J:229771 )

• increase in transepidermal water loss indicating barrier dysfunction

dermatitis ( J:229771 )

• mice exhibit eczematous inflammation

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes and Th17, Th22, and Tgammadelta17 inflammation in skin

abnormal skin morphology ( J:229771 )

• mice exhibit skin microbiome dysbiosis, showing increased Corynebacterium spp and S. aureus colonization

abnormal epidermal layer morphology ( J:229771 )

• increase in IL-22 producing epidermal T cells

immune system

increased T-helper 1 cell number ( J:229771 )

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes

increased T-helper 17 cell number ( J:229771 )

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes

increased T-helper 2 cell number ( J:229771 )

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes

increased IgE level ( J:229771 )

• elevation in serum IgE concentrations

dermatitis ( J:229771 )

• mice exhibit eczematous inflammation

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes and Th17, Th22, and Tgammadelta17 inflammation in skin

hematopoietic system

increased T-helper 1 cell number ( J:229771 )

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes

increased T-helper 17 cell number ( J:229771 )

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes

increased T-helper 2 cell number ( J:229771 )

• mice exhibit mixed Th1, Th2, and Th17 cell accumulations in lymph nodes

increased IgE level ( J:229771 )

• elevation in serum IgE concentrations

homeostasis/metabolism

impaired skin barrier function ( J:229771 )

• increase in transepidermal water loss indicating barrier dysfunction

Allelic Composition	Egfr^tm1Dwt/Egfr^tm1Dwt Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Dwt mutation (1 available); any Egfr mutation (88 available)
Tg(KRT14-cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Wavy coat in Egfr^tm1Dwt/Egfr^tm1Dwt Tg(KRT14-cre)1Amc/0 mice

integument

waved hair ( J:145161 )

Allelic Composition	Egfr^tm1Dwt/Egfr^tm1Dwt Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Dwt mutation (1 available); any Egfr mutation (88 available)
Tg(KRT14-cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:145069 )

N	• skin innervation is normal

integument

abnormal hair follicle morphology ( J:145069 )

• hair follicles are disorganized at P7 to P8

Allelic Composition	Egfr^tm1Dwt/Egfr^tm1Dwt Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Dwt mutation (1 available); any Egfr mutation (88 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placenta abnormalities in Egfr^tm1Dwt/Egfr^tm1Dwt Tg(EIIa-cre)C5379Lmgd/0 mice

embryo

decreased embryo size ( J:145161 )

• at mid-gestation

abnormal spongiotrophoblast layer morphology ( J:145161 )

• mice exhibit similar defects to those observed in Egfr^tm1Mag homozygotes

• the numbers of trophoblasts and glycogen cells in the spongiotrophoblast is moderately to severely reduced compared to in wild-type mice

abnormal placenta labyrinth morphology ( J:145161 )

• mice exhibit similar defects to those observed in Egfr^tm1Mag homozygotes

• the labyrinth is reduced in size and disorganized compared to in wild-type mice

placental labyrinth hypoplasia ( J:145161 )

growth/size/body

decreased embryo size ( J:145161 )

• at mid-gestation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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