Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx2tm1Pa
Name:	T-box 2; targeted mutation 1, Virginia Papaioannou
MGI ID:	MGI:3505715
Synonyms:	Tbx2-
Gene:	Tbx2  Location: Chr11:85723441-85732774 bp, + strand  Genetic Position: Chr11, 51.34 cM
Alliance:	Tbx2tm1Pa page

Germline Transmission:	Earliest citation of germline transmission: J:93610
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The first two exons of the T-box coding sequence were deleted following the incorporation and subsequent deletion of a floxed PGK-neo-TK cassette. (J:93610)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx2 Mutation:	27 strains or lines available

Original:	J:93610 Harrelson Z, et al., Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004 Oct;131(20):5041-52
All:	5 reference(s)