Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tbx2tm1Pa targeted mutation 1, Virginia Papaioannou MGI:3505715 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5 some homozygous embryos are dead
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• at E10.5 the atrioventricular canal fails to constrict in some mutant embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E11.5, 42% of homozygous embryos are dead and by E14.5 all homozygous embryos are dead
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• the 6th arch artery abnormally persists at E12.5 in about 50% of mutant embryos
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• the endocardial cushions are smaller than normal in both the atrioventricular canal and the outflow tract
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• septation is delayed by about 0.5 days
• the aorta is positioned to the right of the pulmonary trunk and not aligned normally with the left ventricle at E12.5
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• at E9.5 and E10.5 the atrioventricular canal fails to constrict in some mutant embryos
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• the endocardial cushions are smaller than normal in both the atrioventricular canal and the outflow tract
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• at E9.5 the ventricle is enlarged or dilated in some mutant embryos
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• pericardial edema is seen at E10.5
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• pericardial edema is seen at E10.5
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• general edema is seen at E10.5
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• bilateral, hindlimb-specific duplication of digit IV is seen
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• the 6th arch artery abnormally persists at E12.5 in about 50% of mutant embryos
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• the 6th arch artery abnormally persists at E12.5 in about 50% of mutant embryos
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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