Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(MCL1)8Caig
Name:	transgene insertion 8, Ruth W Craig
MGI ID:	MGI:3505550
Transgene:	Tg(MCL1)8Caig  Location: unknown
Alliance:	Tg(MCL1)8Caig page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(MCL1)8Caig expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MCL1 (4170) Mcl1  (MGI:101769)   Mutation details: The transgene contains the entire human MCL1 gene, including the endogenous MCL1 promoter. Hemizygous transgenic mice expressed human MCL1 in bone marrow, lymph node, thymus, and spleen (both B- and T-cell populations). Low levels of transgene expression were found in the kidney, small intestine, uterus, lung and liver. (J:50604)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:50604 Zhou P, et al., Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood. 1998 Nov 1;92(9):3226-39
All:	5 reference(s)