Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sncatm1Sud
Name:	synuclein, alpha; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:3487373
Synonyms:	alpha-
Gene:	Snca  Location: Chr6:60708559-60806839 bp, - strand  Genetic Position: Chr6, 29.15 cM
Alliance:	Sncatm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:93686
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The first coding exon, encoding residues 1-40, was deleted via homologous recombination. Immunoblotting confirmed the lack of protein in mutant mice brains. (J:93686)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Snca Mutation:	34 strains or lines available

Original:	J:93686 Schluter OM, et al., Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience. 2003;118(4):985-1002
All:	16 reference(s)