Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nmutm1Mko
Name:	neuromedin U; targeted mutation 1, Masayasu Kojima
MGI ID:	MGI:3056512
Synonyms:	NMKO, Nmu-
Gene:	Nmu  Location: Chr5:76481342-76511624 bp, - strand  Genetic Position: Chr5, 40.93 cM
Alliance:	Nmutm1Mko page

Germline Transmission:	Earliest citation of germline transmission: J:93213
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: PGK-Neo replaced exon 9 (the active C-terminal portion of Nmu) via homologous recombination. Immunohistochemistry confirms the absence of protein. (J:93213)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nmu Mutation:	18 strains or lines available

Original:	J:93213 Hanada R, et al., Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med. 2004 Oct;10(10):1067-73
All:	15 reference(s)