About   Help   FAQ
Tnfaip3tm1Ama
Targeted Allele Detail
Summary
Symbol: Tnfaip3tm1Ama
Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Averil Ma
MGI ID: MGI:3055173
Synonyms: A20-
Gene: Tnfaip3  Location: Chr10:18876658-18891158 bp, - strand  Genetic Position: Chr10, 8.08 cM
Alliance: Tnfaip3tm1Ama page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo in reverse transcription orientation replaced exons 1-4, encompassing the ATG initiation codon and residues 1-246. (J:92931)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfaip3 Mutation:  43 strains or lines available
References
Original:  J:92931 Lee EG, et al., Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science. 2000 Sep 29;289(5488):2350-4
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory