Tg(KRT10BMP6)VI632Mbl Transgene Detail MGI Mouse (MGI:3054946)

Tg(KRT10BMP6)VI632Mbl
Transgene Detail

Summary

Symbol:	Tg(KRT10BMP6)VI632Mbl
Name:	transgene insertion VI632, Manfred Blessing
MGI ID:	MGI:3054946
Transgene:	Tg(KRT10BMP6)VI632Mbl Location: unknown
Alliance:	Tg(KRT10BMP6)VI632Mbl page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(KRT10BMP6)VI632Mbl expresses 1 gene

Mutation details: The transgene contains the human bone morphogenic protein 6 (BMP6) gene under the control of the bovine keratin 10 promoter. (J:36521)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice on an FVB background appear normal at birth, but begin to show skin abnormalities at about 6 days of age. Inflammatory lesions develop by 2-3 weeks of age. The skin condition progressively worsens and is characterized by hair loss, flaky skin, and nail abnormalities. As the transgene inserted into the Y Chromosome, only males are affected.

References

Original:	J:36521 Blessing M, et al., Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J Cell Biol. 1996 Oct;135(1):227-39
All:	2 reference(s)

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