Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Maltm1Nsw Name: myelin and lymphocyte protein, T cell differentiation protein; targeted mutation 1, Nicole Shaeren-Wiemers MGI ID: MGI:3053860 Synonyms: Mal- Gene: Mal  Location: Chr2:127475146-127498615 bp, - strand  Genetic Position: Chr2, 62.06 cM Alliance: Maltm1Nsw page

Compact myelin of Maltm1Nsw/Maltm1Nsw mice contains cytoplasmic inclusions Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:92517
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ/neo cassette was inserted in frame after the third codon in exon 1, replacing the remainder of exon 1. Southern blot confirmed recombination in mutant mice. Northern blot indicated a lack of full-length transcript in homozygotes, but presence of a lacZ-containing transcript in homozygotes and heterozygotes. Absence of wild-type protein was demonstrated by an immunohistochemistry assay of sciatic nerves and brain from mutants. (J:92517)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mal Mutation:	17 strains or lines available

Original:	J:92517 Schaeren-Wiemers N, et al., The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system. J Cell Biol. 2004 Aug 30;166(5):731-42
All:	6 reference(s)