Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scn10atm2(cre)Jwo
Name:	sodium channel, voltage-gated, type X, alpha; targeted mutation 2, John N Wood
MGI ID:	MGI:3053096
Synonyms:	nav1.8-cre, Nav1.8Cre, NaV1.8Cre, Scn10atm2(cre)Jnw
Gene:	Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance:	Scn10atm2(cre)Jwo page

Germline Transmission:	Earliest citation of germline transmission: J:92442
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Scn10atm2(cre)Jwo expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Scn10a (MGI:108029)   Mutation details: Cre recombinase, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. Cre expression was observed beginning at embryonic day 14 in small-diameter neurons in dorsal root, trigeminal, and nodose ganglia but absent in nonneuronal and CNS tissues. (J:92442)

Activity:	Tissue activity of this recombinase allele
Driver:	Scn10a (mouse) Summary of all recombinase alleles driven by Scn10a. Comparative matrix view of recombinase activities Alliance mouse Scn10a gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

38 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:	102 strains or lines available

Original:	J:92442 Nassar MA, et al., Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12706-11
All:	109 reference(s)