Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myocdtm1Eno
Name:	myocardin; targeted mutation 1, Eric N Olson
MGI ID:	MGI:3052940
Synonyms:	myocardin-
Gene:	Myocd  Location: Chr11:65067387-65160815 bp, - strand  Genetic Position: Chr11, 40.42 cM
Alliance:	Myocdtm1Eno page

Germline Transmission:	Earliest citation of germline transmission: J:84789
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A promoterless lacZ gene and a neomycin selection cassette replaced exons 8 and 9, which encode the basic domain, the glutamine-rich domain and part of the SAP domain. These domains are required for the normal function of the gene. RT-PCR analysis demonstrated that no detectable transcript was expressed from this allele in homozygous mice. (J:84789)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myocd Mutation:	53 strains or lines available

Original:	J:84789 Li S, et al., The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9366-70
All:	4 reference(s)