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Eportm1.1(EGFP/icre)Uk
Targeted Allele Detail
Summary
Symbol: Eportm1.1(EGFP/icre)Uk
Name: erythropoietin receptor; targeted mutation 1.1, Ursula Klingmuller
MGI ID: MGI:3052727
Synonyms: EpoRCre, EpoR-iCre, Eportm1.1(EGFP/icre)Uk, ErGFPcre
Gene: Epor  Location: Chr9:21870193-21874802 bp, - strand  Genetic Position: Chr9, 7.93 cM
Alliance: Eportm1.1(EGFP/icre)Uk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92235
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Eportm1.1(EGFP/icre)Uk expression driven by 1 gene
 
Mutation detailsAn EGFP/icre sequence was inserted into exon 1, replacing the endogenous ATG with the translational start site of the EGFP/icre, yet preserving the last 10 bp of the splice-donor site of exon 1. A FRT flanked neo was inserted downstream to replace parts of exon 2 and exons 3-8. Transient FLP expression excised the neo. Southern blot and multiplex PCR confirmed recombination in heterozygous mice. Immunoblot of FLCs demonstrated green fluorescence in heterozygous and homozygous embryos, with homozygotes showing a 2-fold increase in fluorescence intensity compared to heterozygotes. (J:92235)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Epor (mouse)
Summary of all recombinase alleles driven by Epor.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
4 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Epor Mutation:  25 strains or lines available
References
Original:  J:92235 Heinrich AC, et al., A mouse model for visualization and conditional mutations in the erythroid lineage. Blood. 2004 Aug 1;104(3):659-66
All:  75 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory