Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam1atm1Tba
Name:	a disintegrin and metallopeptidase domain 1a; targeted mutation 1, Tadashi Baba
MGI ID:	MGI:3052660
Synonyms:	Adam1a-
Gene:	Adam1a  Location: Chr5:121656667-121659758 bp, - strand  Genetic Position: Chr5, 61.84 cM
Alliance:	Adam1atm1Tba page

Germline Transmission:	Earliest citation of germline transmission: J:92271
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The protein-coding region containing the pro-, metalloprotease, disintegrin and cysteine rich domains were replaced with a neo via homologous recombination. Northern blot of mutant testes indicated lack of transcript and Western blot of testicular germ cells of mutants showed complete absence of the precursor form of the protein. (J:92271)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam1a Mutation:	24 strains or lines available

Original:	J:92271 Nishimura H, et al., Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface. J Biol Chem. 2004 Aug 13;279(33):34957-62
All:	2 reference(s)