Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(HLA-A2/H2-K)1Scr
Name:	transgene insertion 1, The Scripps Research Institute
MGI ID:	MGI:3050815
Synonyms:	CyHLA A2.1/Kb
Transgene:	Tg(HLA-A2/H2-K)1Scr  Location: unknown
Alliance:	Tg(HLA-A2/H2-K)1Scr page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(HLA-A2/H2-K)1Scr expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse H2-K (MGI:3040519)   Mutation details: The transgene expresses a human-mouse chimeric major histocompatibility class I protein composed of the leader sequence and the alpha1 and alpha2 domains of HLA-A2.1 joined to the alpha3, cytoplasmic and transmembrane domains of H2-Kb. Mice expressing this transgene exhibit HLA-A2.1-restricted CD8 T-cell responses to appropriate antigens. (J:91744)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:91745 Sherman LA, C57BL/6J mice with MHC class I-H2 chimeric transgene can be used to identify HLA-A2.1 restricted peptide epitopes. MGI Direct Data Submission. 2004;
All:	8 reference(s)