Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: A1cfTg(Myh6-cre/Esr1*)1Jmk Name: APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin MGI ID: MGI:3050453 Synonyms: alphaMHC-Cre-Mer-Cre, alpha-MHC-MerCreMer, CM-MCM, MCM, mer, mER-CRE-mER, MerCreMer, Myh6-MerCreMer, Myh6:MerCreMer, Tg(Myh6-cre/Esr1)1Jmk Gene: A1cf  Location: Chr19:31846164-31926395 bp, + strand  Genetic Position: Chr19, 26.58 cM, cytoband C3 Alliance: A1cfTg(Myh6-cre/Esr1*)1Jmk page

The Med1tm2Jkr/Med1tm2Jkr A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ mouse heart is flaccid and flabby after tamoxifen induction. Show the 6 phenotype image(s) involving this allele.

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   A1cfTg(Myh6-cre/Esr1*)1Jmk expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Myh6 (MGI:97255)   Mutation details: This transgene expresses a cre recombinase/ mutant estrogen receptor ligand binding domain fusion protein under the control of a mouse cardiac-specific alpha-myosin heavy chain promoter. Expression was detected in the juvenile and adult heart, but the protein is inactive until induced with tamoxifen. Integration of the transgene in to Chr. 19 deleted a 19,500 bp fragment including the promoter, exon 1, and part of intron 1 of the A1cf gene. Western analysis of liver from homozygous transgenic mice does not detect A1cf protein. (J:82027, J:231727)

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (mouse) Summary of all recombinase alleles driven by Myh6. Comparative matrix view of recombinase activities Alliance mouse Myh6 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any A1cf Mutation:	39 strains or lines available

Original:	J:82027 Sohal DS, et al., Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res. 2001 Jul 6;89(1):20-5
All:	472 reference(s)