Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabra6tm2(cre)Wwis
Name:	gamma-aminobutyric acid type A receptor subunit alpha 6; targeted mutation 2, W Wisden
MGI ID:	MGI:3047798
Synonyms:	delta alpha6Cre
Gene:	Gabra6  Location: Chr11:42197264-42211899 bp, - strand  Genetic Position: Chr11, 25.03 cM
Alliance:	Gabra6tm2(cre)Wwis page

Germline Transmission:	Earliest citation of germline transmission: J:91624
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Gabra6tm2(cre)Wwis expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gabra6 (MGI:95618)   Mutation details: Exon 8 was disrupted by insertion, via homologous recombination, of a TAG3 IRES-nlsCre-neo cassette, which contains stop codons in all reading frames followed by an encephalomyelocarditis virus internal ribosome entry site (IRES), the coding sequence for Cre recombinase flanked by the nuclear localization sequence and polyadenylation signal from SV40, and a neomycin resistance gene driven by the HSV promoter. Cre was shown, both by immunohistochemistry and by X-gal staining of brains of adult F1 progeny from a cross to a beta-galactosidase expressing Cre reporter strain, to be expressed uniformly in nuclei of all cells of the granule cell layer and, additionally, in a few Purkinje cells and in some small cells in the molecular layer. (J:91624)

Activity:	Tissue activity of this recombinase allele
Driver:	Gabra6 (mouse) Summary of all recombinase alleles driven by Gabra6. Comparative matrix view of recombinase activities Alliance mouse Gabra6 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gabra6 Mutation:	38 strains or lines available

Original:	J:91624 Aller MI, et al., Cerebellar granule cell Cre recombinase expression. Genesis. 2003 Jun;36(2):97-103
All:	22 reference(s)