Grem1<tm1Azun> Targeted Allele Detail MGI Mouse (MGI:3046937)

Grem1^tm1Azun
Targeted Allele Detail

Summary

Symbol:	Grem1^tm1Azun
Name:	gremlin 1, DAN family BMP antagonist; targeted mutation 1, Aimee Zuniga
MGI ID:	MGI:3046937
Synonyms:	deltaGre, Gre^deltaORF, Grem1^delta, Gremlin^-
Gene:	Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
Alliance:	Grem1^tm1Azun page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:90991
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire 552 bp CDS encoded by exon 2 and 132 bp of the 3' UTR were deleted and replaced by an IRES-lacZ cassette and a loxP site flanked neomycin resistance gene cassette. In situ hybridization of heterozygous embryos show identical distribution of wild-type and mutant allele expression. (J:90991)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Grem1 Mutation:	16 strains or lines available

Notes

This mutation was determined to be allelic to both Fmn1^{ld-Is(17;In2)1Gso} and Fmn1^tm1.1Zlr through complementation analyses (J:91385). Transcription was not detected in the limb bud mesenchyme of either type of compound heterozygous mutant embryo. This allele is allelic to Grem1^ld (J:91385) as well. In each case, compound heterozygous mutant mice display the mutant "limb deformity" limb phenotype.

References

Original:	J:90991 Michos O, et al., Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development. 2004 Jul;131(14):3401-10
All:	10 reference(s)

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