Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm7Sia
Name:	orthodenticle homeobox 2; targeted mutation 7, Shinichi Aizawa
MGI ID:	MGI:3046841
Synonyms:	Otx2deltaAN, Otx2deltaAN1
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm7Sia page

Germline Transmission:	Earliest citation of germline transmission: J:91012
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The anterior neuroectoderm (AN) enhancer region (559 bp) was replaced with a floxed neomycin-resistance gene. Southern blot confirmed recombination and quantitative RT-PCR confirmed a reduction in gene expression in mutant embryos. (J:91012)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:91012 Kurokawa D, et al., Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development. 2004 Jul;131(14):3307-17
All:	3 reference(s)