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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm7Sia
targeted mutation 7, Shinichi Aizawa
MGI:3046841
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otx2tm7Sia/Otx2tm7Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3056055
ht2
 		Otx2tm2.1Imat/Otx2tm7Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3718488
cn3
 		Otx2tm7Sia/Otx2+
Tg(Lefty2-cre)21bHmd/? 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3718487
cx4
 		Emx2tm1Sia/Emx2tm1Sia
Otx2tm7Sia/Otx2tm7Sia 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3056075


Genotype
MGI:3056055
hm1
Allelic
Composition		 Otx2tm7Sia/Otx2tm7Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm7Sia mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:91012 )
N
• the epiblast develops normally
• axis rotation occurs normally

nervous system
nervous system phenotype ( J:91012 )
N
• forebrain and midbrain develop normally




Genotype
MGI:3718488
ht2
Allelic
Composition		 Otx2tm2.1Imat/Otx2tm7Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm2.1Imat mutation (0 available); any Otx2 mutation (51 available)
Otx2tm7Sia mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:91012 )
N
• axis rotation occurs normally

nervous system
abnormal forebrain development ( J:91012 )
• at E12.5, forebrain defects range from mild to severe
absent midbrain ( J:91012 )
• at E12.5, in severe cases the midbrain is absent
absent forebrain ( J:91012 )
• in some cases the forebrain is absent




Genotype
MGI:3718487
cn3
Allelic
Composition		 Otx2tm7Sia/Otx2+
Tg(Lefty2-cre)21bHmd/?
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm7Sia mutation (1 available); any Otx2 mutation (51 available)
Tg(Lefty2-cre)21bHmd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:91012 )
N
• axis rotation occurs normally




Genotype
MGI:3056075
cx4
Allelic
Composition		 Emx2tm1Sia/Emx2tm1Sia
Otx2tm7Sia/Otx2tm7Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2tm1Sia mutation (1 available); any Emx2 mutation (22 available)
Otx2tm7Sia mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent diencephalon ( J:91012 )
• the diencephalon is lost




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory