Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx1tm4(cre/Esr1*)Bld
Name:	T-box 1; targeted mutation 4, Antonio Baldini
MGI ID:	MGI:3046795
Synonyms:	Tbx1mcm, Tbx1tm4(cre/Esr1)Bld
Gene:	Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance:	Tbx1tm4(cre/Esr1*)Bld page

Germline Transmission:	Earliest citation of germline transmission: J:91013
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tbx1tm4(cre/Esr1*)Bld expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tbx1 (MGI:98493)   Mutation details: An IRES and MerCreMer fusion gene were inserted into exon 5 via homologous recombination. This is the same insertion site as in Tbx1tm1Bld. This results in tamoxifen-inducible cre expression under the control of the endogenous Tbx1 promoter. (J:91013)

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx1 (mouse) Summary of all recombinase alleles driven by Tbx1. Comparative matrix view of recombinase activities Alliance mouse Tbx1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:	34 strains or lines available

Original:	J:91013 Xu H, et al., Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul;131(13):3217-27
All:	10 reference(s)