Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chek1tm1Jmr
Name:	checkpoint kinase 1; targeted mutation 1, Jeffrey M Rosen
MGI ID:	MGI:3046694
Synonyms:	Chk1 Flox
Gene:	Chek1  Location: Chr9:36619935-36637897 bp, - strand  Genetic Position: Chr9, 20.67 cM, cytoband A5.3
Alliance:	Chek1tm1Jmr page

Germline Transmission:	Earliest citation of germline transmission: J:91266
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted around a 2.2kb genomic segment containing exon 2 via homologous recombination. (J:91266)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chek1 Mutation:	41 strains or lines available

Original:	J:91266 Lam MH, et al., Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 2004 Jul;6(1):45-59
All:	11 reference(s)