Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp3r1tm1Grc
Name:	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); targeted mutation 1, Gerald R Crabtree
MGI ID:	MGI:3043986
Synonyms:	CnB*
Gene:	Ppp3r1  Location: Chr11:17109298-17150380 bp, + strand  Genetic Position: Chr11, 9.71 cM, cytoband A3.1
Alliance:	Ppp3r1tm1Grc page

Germline Transmission:	Earliest citation of germline transmission: J:70266
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutation:    Other   Mutation details: Sequence encoding an FRB* peptide tag was inserted into exon 5, immediately following the last codon of the coding sequence. This allele produces a protein with a C-terminal FRB* peptide tag that prevents interaction with PPP3CA, thereby eliminating calcium-dependent activation of PPP3CA catalytic activity. An assay indicated the abrogation of caclcineurin phosphatase activity. (J:70266)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp3r1 Mutation:	30 strains or lines available

Original:	J:70266 Graef IA, et al., Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
All:	1 reference(s)