Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pla2g5tm1Jarm
Name:	phospholipase A2, group V; targeted mutation 1, Jonathan P Arm
MGI ID:	MGI:3042209
Synonyms:	Group V sPLA2-null
Gene:	Pla2g5  Location: Chr4:138526558-138590780 bp, - strand  Genetic Position: Chr4, 70.57 cM
Alliance:	Pla2g5tm1Jarm page

Germline Transmission:	Earliest citation of germline transmission: J:89490
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was deleted and replaced with a neo cassette lacking a poladenylation signal via homologous recombination. Only abnormal short transcripts were detected by northern blotting and RT-PCR in homozygous mice. Immunofluorescence confirmed the absence of protein expression. (J:89490)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pla2g5 Mutation:	21 strains or lines available

Original:	J:89490 Satake Y, et al., Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J Biol Chem. 2004 Apr 16;279(16):16488-94
All:	22 reference(s)