Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation
(0 available);
any
Pla2g5 mutation
(21 available)
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immune system
N |
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal edema
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• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
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hematopoietic system
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• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
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cellular
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• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation
(0 available);
any
Pla2g5 mutation
(21 available)
|
|
|
immune system
|
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis
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hematopoietic system
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• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis
|
cellular
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• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation
(0 available);
any
Pla2g5 mutation
(21 available)
|
|
|
immune system
|
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
|
hematopoietic system
|
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
|
cellular
|
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation
(0 available);
any
Pla2g5 mutation
(21 available)
|
|
|
immune system
hematopoietic system
cellular
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation
(0 available);
any
Pla2g5 mutation
(21 available)
|
|
|
immune system
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• arachadonic acid metabolite release from zymosan-stimulated peritoneal macrophages is reduced
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• a reduction in plasma exudation is seen 30 minutes but not 60 minutes after intraperitoneal injection of a zymosan suspension in homozygotes compared to wild-type mice
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hematopoietic system
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• arachadonic acid metabolite release from zymosan-stimulated peritoneal macrophages is reduced
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