Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Setdb1tm1Enl
Name:	SET domain, bifurcated 1; targeted mutation 1, En Li
MGI ID:	MGI:3040431
Synonyms:	Eset-
Gene:	Setdb1  Location: Chr3:95230836-95264513 bp, - strand  Genetic Position: Chr3, 40.74 cM, cytoband F2
Alliance:	Setdb1tm1Enl page

Germline Transmission:	Earliest citation of germline transmission: J:89058
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 15-22 were replaced with an IRES-betageo cassette. These exons encode the pre- and post-SET catalytic region of the protein, and removal was predicted to abolish all activity. X-gal staining detected lacZ expression in homozygous embryos. (J:89058)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Setdb1 Mutation:	56 strains or lines available

Original:	J:89058 Dodge JE, et al., Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol. 2004 Mar;24(6):2478-86
All:	1 reference(s)