Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfsf13tm1Geha
Name:	tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Raif S Geha
MGI ID:	MGI:3038886
Synonyms:	APRIL-
Gene:	Tnfsf13  Location: Chr11:69573672-69576610 bp, - strand  Genetic Position: Chr11, 42.86 cM, cytoband B4
Alliance:	Tnfsf13tm1Geha page

Germline Transmission:	Earliest citation of germline transmission: J:88910
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of of exon 3 and all of exons 4 through 6 were replaced by homologous recombination with a neo cassette in the opposite orientation of the endogenous gene. These exons encode the last 126 amino acids of the 201 amino acid long extracellular domain. RT-PCR of spleen and bone marrow indicated no transcript was present in mutant mice; in contrast, mRNA expression of Tnfsf12 and Senp3 (which flank within ~1 kb) in spleen was normal. (J:88910)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf13 Mutation:	68 strains or lines available

Original:	J:88910 Castigli E, et al., Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3903-8
All:	5 reference(s)