Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Myh6-Prkca)1Jmk
Name:	transgene insertion 1, Jeffery D Molkentin
MGI ID:	MGI:3037092
Transgene:	Tg(Myh6-Prkca)1Jmk  Location: unknown
Alliance:	Tg(Myh6-Prkca)1Jmk page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Myh6-Prkca)1Jmk expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Prkca (MGI:97595)   Mutation details: Wild-type mouse Prkca cDNA was adjoined to 5.5 kb of murine Myh6 promoter to drive expression of Prkca in a cadriac-specific manner. Quantitative Western blotting revealed a five-fold increase of PRKCA in cardiac tissue. (J:88510)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:88510 Braz JC, et al., PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004 Mar;10(3):248-54
All:	1 reference(s)