Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Tg(Pdx1-cre)6Tuv Name: transgene insertion 6, David A Tuveson MGI ID: MGI:3032531 Synonyms: Pdx1-cre, PDX-1-Cre, Pdx1-CreTg, Pdx1-CreTuv, Tg(Ipf1-cre)1Tuv, Tg(Ipf1-cre)6Tuv Transgene: Tg(Pdx1-cre)6Tuv  Location: unknown  Genetic Position: Chr8, Syntenic Alliance: Tg(Pdx1-cre)6Tuv page

Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue Show the 2 phenotype image(s) involving this allele.

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Pdx1-cre)6Tuv expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Pdx1   Mutation details: The transgenic construct is composed of a Cre recombinase coding sequence under the control of the Pdx1 promoter. Cre expression is thus directed to islet cells of the pancreas. Line 6 was inserted into chromosome 8 about 48 kb upstream of Zfp423 (chr8:90,531,639; NCBI37/mm9) with elements of human ACTB 3'UTR and polyA signal, and a 1.5 kb genomic duplication at the integration site. (J:87973, J:240920)

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (species not specified) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

23 assay results 9 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Pdx1-cre)6Tuv

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available

Original:	J:87973 Hingorani SR, et al., Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec;4(6):437-50
All:	428 reference(s)