Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Vegfctm1Ali
Name:	vascular endothelial growth factor C; targeted mutation 1, Kari Alitalo
MGI ID:	MGI:3026650
Synonyms:	Vegfc-, VegfcLacZ, Vegfclz
Gene:	Vegfc  Location: Chr8:54530567-54639489 bp, + strand  Genetic Position: Chr8, 29.2 cM, cytoband B3
Alliance:	Vegfctm1Ali page

Germline Transmission:	Earliest citation of germline transmission: J:87394
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of first coding exon, including the start codon and the coding region, was replaced with a lacZ and neo cassette inserted by homologous recombination. RT-PCR analysis of homozygous mutant embryos indicated that no normal transcript was produced from this loci. LacZ transcript was detected by RT-PCR analysis of mutant embryos. (J:87394)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vegfc Mutation:	27 strains or lines available

Original:	J:87394 Karkkainen MJ, et al., Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 2004 Jan;5(1):74-80
All:	21 reference(s)