Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Neurog3-cre/Esr1*)1Dam
Name:	transgene insertion 1, Douglas A Melton
MGI ID:	MGI:2684324
Synonyms:	Ngn3-Cre, Ngn3/CreERTM, Tg(Neurog3-cre/Esr1)1Dam
Transgene:	Tg(Neurog3-cre/Esr1*)1Dam  Location: unknown
Alliance:	Tg(Neurog3-cre/Esr1*)1Dam page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Neurog3-cre/Esr1*)1Dam expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Neurog3   Mutation details: The sequence encoding a tamoxifen-inducible form of a cre recombinase/estrogen receptor fusion protein was adjoined to a 6.7 kb Neurog3 promoter fragment. The neurogenin 3 promoter drives the expression of cre recombinase in the islet cells of the pancreas. (J:76095)

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (species not specified) Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:76095 Gu G, et al., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57
All:	18 reference(s)