Summary | Transgene origin | Transgene description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Fabp1-Ccnd1)4Rdb
Name:	transgene insertion 4, R Daniel Beauchamp
MGI ID:	MGI:2684226
Transgene:	Tg(Fabp1-Ccnd1)4Rdb  Location: unknown
Alliance:	Tg(Fabp1-Ccnd1)4Rdb page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Fabp1-Ccnd1)4Rdb expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Ccnd1 (MGI:88313)   Mutation details: This transgenic construct contains the mouse cyclin D1 gene driven by the rat fatty acid binding protein promoter. Transgenic mice overexpress cyclin D1 in the liver and epithelial cells of the small intestine and colon. A lower level of expression occurs in the kidneys. This line carries 20-fold more transgene copies than the F2 line, which itself carries multiple transgene copies. (J:70394)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Fabp1-Ccnd1)4Rdb

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:70394 Deane NG, et al., Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res. 2001 Jul 15;61(14):5389-95
All:	2 reference(s)