Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mcl1tm3Sjk
Name:	myeloid cell leukemia sequence 1; targeted mutation 3, Stanley J Korsmeyer
MGI ID:	MGI:2684151
Synonyms:	F-Mcl-1, Mcl-1f, Mcl-1flox
Gene:	Mcl1  Location: Chr3:95566099-95570487 bp, + strand  Genetic Position: Chr3, 40.74 cM
Alliance:	Mcl1tm3Sjk page

Germline Transmission:	Earliest citation of germline transmission: J:86906
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Single loxP sites flank exon 1, which contains the start codon. Western blot analysis of lysates of thymocytes showed the level of protein in mutant mice to be comparable to that in wild-type mice. (J:86906)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	42 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcl1 Mutation:	33 strains or lines available

Original:	J:86906 Opferman JT, et al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003 Dec 11;426(6967):671-6
All:	46 reference(s)