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Nkx1-1tm1Tlu
Targeted Allele Detail
Summary
Symbol: Nkx1-1tm1Tlu
Name: NK1 homeobox 1; targeted mutation 1, Thomas Lufkin
MGI ID: MGI:2684149
Gene: Nkx1-1  Location: Chr5:33588078-33591320 bp, - strand  Genetic Position: Chr5, 17.65 cM
Alliance: Nkx1-1tm1Tlu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86868
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequence at the end of exon 2 and at the beginning of intron 2 was replaced with an IRES-lacZ and floxed neomycin resistance gene. This results in the production of a truncated, non functional protein. (J:86868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx1-1 Mutation:  13 strains or lines available
References
Original:  J:86868 Simon R, et al., Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory