Phenotypes associated with this allele

• Allele Symbol: Nkx1-1^tm1Tlu
• Allele Name: targeted mutation 1, Thomas Lufkin
• Allele ID: MGI:2684149
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx1-1^tm1Tlu/Nkx1-1^tm1Tlu	involves: 129 * C57BL/6J	MGI:2684162

Genotype
MGI:2684162

hm1

• Allelic Composition: Nkx1-1^tm1Tlu/Nkx1-1^tm1Tlu
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:86868 )

• 85% died within the first 3 weeks of life

• 2-3 days before death they begin showing signs of wasting

behavior/neurological

decreased grip strength ( J:86868 )

• grip strength is reduced compared to wild-type mice

growth/size/body

postnatal growth retardation ( J:86868 )

• normal size at birth

• grew very slowly after birth

reproductive system

reduced fertility ( J:86868 )

• those mice reaching adulthood were fertile

• offspring from interbreeding homozygotes died within 4 days