Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Becn1tm1Blev
Name:	beclin 1, autophagy related; targeted mutation 1, Beth Levine
MGI ID:	MGI:2683696
Synonyms:	Atg6-, beclin 1-
Gene:	Becn1  Location: Chr11:101179084-101193112 bp, - strand  Genetic Position: Chr11, 64.58 cM, cytoband D
Alliance:	Becn1tm1Blev page

Germline Transmission:	Earliest citation of germline transmission: J:86953
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 1 and 2 were replace with a neomycin selection cassette inserted by homologous recombination. (J:86953)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

List all tumor models in MMHCdb carrying Becn1tm1Blev

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Becn1 Mutation:	35 strains or lines available

Original:	J:86953 Qu X, et al., Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003 Dec;112(12):1809-20
All:	56 reference(s)