Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Leprdb-5J
Name:	leptin receptor; diabetes 5 Jackson
MGI ID:	MGI:2683234
Gene:	Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance:	Leprdb-5J page

Strain of Origin:

NOD/ShiLtJ

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A G-to-T mutation was found in exon 13 effecting a glycine 640 to valine (p.G640V) change in the receptor. (J:87061) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:	121 strains or lines available

Original:	J:87061 Leiter EH, et al., Leptin receptor deficiency in NOD/LtJ mice produces a type 2 diadetes syndrome with suppressed autoimmunity. MGI Direct Data Submission. 2004;
All:	3 reference(s)