Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gna11Mhdadsk7
Name:	guanine nucleotide binding protein, alpha 11; Martin Hrabe de Angelis dark skin 7
MGI ID:	MGI:2682213
Synonyms:	dark skin 7, Dsk7, Gna11Dsk7
Gene:	Gna11  Location: Chr10:81364558-81380996 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Gna11Mhdadsk7 page

Strain of Origin:

C3HeB/FeJ

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: A single base pair mutation causes a non-conservative sequence change of isoleucine to valine at position 63 of the encoded protein. The mutant protein shows hypermorphic activity by genetic interaction tests with other mutant alleles. (J:92947) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gna11 Mutation:	21 strains or lines available

Original:	J:81301 Fitch KR, et al., Genetics of dark skin in mice. Genes Dev. 2003 Jan 15;17(2):214-28
All:	3 reference(s)