Phenotypes associated with this allele

• Allele Symbol: Gna11^Mhdadsk7
• Allele Name: Martin Hrabe de Angelis dark skin 7
• Allele ID: MGI:2682213
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gna11^Mhdadsk7/Gna11^Mhdadsk7	involves: C3HeB/FeJ * C57BL/6J	MGI:3576331
ht2	Gna11^Mhdadsk7/Gna11^+	C3HeB/FeJ-Gna11^Mhdadsk7/Ieg	MGI:2682214

Genotype
MGI:3576331

hm1

• Allelic Composition: Gna11^Mhdadsk7/Gna11^Mhdadsk7
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

darkened coat color ( J:81301 )

• slight darkening of the hair

• more severe in homozygous than heterozygous animals

hyperpigmentation ( J:81301 )

• excess pigmentation is also seen in the dermis of hair-bearing skin

• in homozygotes a large increase in dermal pigmentation and a slight increase in epidermal pigmentation is seen

• excess pigmentation is first seen at P3 increases through weaning then fades slightly with age

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color

• more severe in homozygous than heterozygous animals

increased tail pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the tail

• more severe in homozygous than heterozygous animals

hearing/vestibular/ear

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

limbs/digits/tail

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color

• more severe in homozygous than heterozygous animals

increased tail pigmentation ( J:81301 )

• more severe in homozygous than heterozygous animals

• extremely dark pigmentation in dermis of the tail

craniofacial

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

integument

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

darkened coat color ( J:81301 )

• slight darkening of the hair

• more severe in homozygous than heterozygous animals

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color

• more severe in homozygous than heterozygous animals

increased tail pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the tail

• more severe in homozygous than heterozygous animals

growth/size/body

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

Genotype
MGI:2682214

ht2

• Allelic Composition: Gna11^Mhdadsk7/Gna11⁺
• Genetic Background: C3HeB/FeJ-Gna11^Mhdadsk7/Ieg

pigmentation

darkened coat color ( J:81301 )

• slight darkening of the hair

• more severe in homozygous than heterozygous animals

hyperpigmentation ( J:81301 )

• excess pigmentation is also seen in the dermis of hair-bearing skin

• excess pigmentation is first seen at P3 increases through weaning then fades slightly with age

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color

• more severe in homozygous than heterozygous animals

increased tail pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the tail

• more severe in homozygous than heterozygous animals

hearing/vestibular/ear

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

limbs/digits/tail

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color

• more severe in homozygous than heterozygous animals

increased tail pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the tail

• more severe in homozygous than heterozygous animals

craniofacial

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

integument

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals

darkened coat color ( J:81301 )

• slight darkening of the hair

• more severe in homozygous than heterozygous animals

increased foot pad pigmentation ( J:81301 )

• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color

• more severe in homozygous than heterozygous animals

increased tail pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the tail

• more severe in homozygous than heterozygous animals

growth/size/body

increased ear pigmentation ( J:81301 )

• extremely dark pigmentation in dermis of the ears

• more severe in homozygous than heterozygous animals