Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pnliptm1Dyh
Name:	pancreatic lipase; targeted mutation 1, David Y Hui
MGI ID:	MGI:2681122
Synonyms:	PTL-
Gene:	Pnlip  Location: Chr19:58658797-58670231 bp, + strand  Genetic Position: Chr19, 54.46 cM, cytoband D3
Alliance:	Pnliptm1Dyh page

Germline Transmission:	Earliest citation of germline transmission: J:86414
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 4 was disrupted by a neomycin selection cassette inserted by homologous recombination. The targeted exon has been reported to be essential for enzymatic activity. Protein was undetected in homozygous mutant mice by Western blot analysis of pancreatic extracts. Triglyceride hydrolysis was reduced by approximately 90% in homozygous mutanat mice. (J:86414)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pnlip Mutation:	27 strains or lines available

Original:	J:86414 Huggins KW, et al., Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. J Biol Chem. 2003 Oct 31;278(44):42899-905
All:	4 reference(s)