Tg(rPEPCKSREBF2)788Reh
Transgene Detail
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| Symbol: |
Tg(rPEPCKSREBF2)788Reh |
| Name: |
transgene insertion 788, Robert E Hammer |
| MGI ID: |
MGI:2680523 |
| Synonyms: |
Line B |
| Transgene: |
Tg(rPEPCKSREBF2)788Reh Location: unknown
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| Alliance: |
Tg(rPEPCKSREBF2)788Reh page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(rPEPCKSREBF2)788Reh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SREBF2 (6721) |
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Mutation details: This transgene is composed of the rat Pepck promoter fused to a cDNA encoding amino acids 1-468 of human SREBP-2 followed by 2 stop codons. The 2.4 kb rat Pepck promoter is active in liver and adepose tissue. The cDNA portion encodes the 6HLH-zip domain and the NH2-terminal acidic transactivation domain. It lacks the membrane attachment domain and the COOH-terminal regulatory domain. Production of truncated product was determined by immunoblot analysis.
(J:86518)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:86518 Horton JD, et al., Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest. 1998 Jun 1;101(11):2331-9 |
| All: |
9 reference(s) |
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Analysis Tools
