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Syvn1tm1Tn
Targeted Allele Detail
Summary
Symbol: Syvn1tm1Tn
Name: synovial apoptosis inhibitor 1, synoviolin; targeted mutation 1, Toshihiro Nakajima
MGI ID: MGI:2679656
Synonyms: syno+/-, synoviolin/hrd1+/-
Gene: Syvn1  Location: Chr19:6096606-6103742 bp, + strand  Genetic Position: Chr19, 4.34 cM, cytoband A
Alliance: Syvn1tm1Tn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86009
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing lacZ and neo was inserted at the start codon located in exon 1. Northern and Western blot analyses of homozygous mutant embryos indicated an absence of both transcript and protein. (J:86009)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syvn1 Mutation:  26 strains or lines available
References
Original:  J:86009 Amano T, et al., Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003 Oct 1;17(19):2436-49
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory